PUBLIC HEALTH RESEARCH INSTITUTE

A Center of UMDNJ-New Jersey Medical School At the International Center for Public Health, Newark, NJ, USA

PHRI/NJMS TB Research Programs

David Alland M.D. Drug resistance of M. tuberculosis and PCR-based diagnostics

Yuri Bushkin, Ph.D. Antigen presentation  in the course of mycobacterial infection.

Karl Drlica, Ph.D. Bacterial chromosome structure and fluoroquinolone resistance.

Marila Gennaro, M.D. Immune responses to proteins of M. tuberculosis and  their use for diagnosis. Effects of host immunity on transcription and antigen composition of M. tuberculosis.

Gilla Kaplan, Ph.D. Diverse ways in which patients' immune systems respond to infection with M. tuberculosis and HIV. Clinical research programs in South Africa and other countries.

Barry Kreiswirth, Ph.D. Molecular epidemiology of M. tuberculosis and drug resistance.

Richard Pine, Ph.D.  Gene regulation of cellular response to infection with M. tuberculosis and/or HIV-1, focusing on cytokines and other interactions among cells.

Padmini Salgame, Ph.D. Dendritic cells and T cell polarization in tuberculosi.

Issar Smith, Ph.D. Genetics of M. tuberculosis virulence.

Xilin Zhao, Ph.D. Bacterial stress response, ntimicrobial tolerance, persistence, and resistance.

Fred Kramer, Ph.D. and Sanjay Tyagi, Ph.D. Inventors of molecular beacons. Design of novel nucleic acid molecules for diagnostic and therapeutic application.

Patricia Soteropoulos, Ph.D. Applications and development of microarray technology.

The largest BSL3 pathogen facility in the Northeast USA, with >20,000 sf lab and animal BSL3 capacity

ICPH houses PHRI, Global TB Center, and Dept. of Microbiology and Molecular Genetics
RBL = Regional Biocontainment Laboratory

Gennaro laboratory

• Antibody responses to M. tuberculosis infection and disease
• Characterization of serodiagnostic antigens
• Transcriptional and metabolic pathways to M. tuberculosis growth arrest
• Transcriptional regulatory network of M. tuberculosis$